Information provided and products sold on this site are not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Please consult with your health care provider for recommendations specific to your health. Rajsree Nambudripad, MD has created this content for education and information only. □ For more details and research references, click link below: To learn more tips on treating SIBO, please watch my videos: My patients with SIBO have done well with either Spore Probiotic IgG or Probiotic 100 Billion. This probiotic does not require refrigeration. It can be used during SIBO treatment as well after SIBO treatment as a maintenance probiotic. The full dose is 3 capsules, so start with 1 and gradually work up to 3 capsules every morning. Take 1-3 capsules in AM on empty stomach. It may also help in reducing adverse food reactions. IgG also helps reduce gut inflammation and prevent autoimmune tendencies that start in the gut. The Immunoglobulins (IgG Antibodies) help to bind bacterial toxins and microbes that cause die-off symptoms during SIBO treatment. This randomized control study published in 2019 shows the efficacy of spore-based probiotics in IBS and SIBO patients: Spores can survive hostile environments like stomach acid and have a longer life of activity in the intestines (21 days vs 7 days). Spores are dormant, soil-organisms that germinate in the intestines. This is a Bacillus based spore-based probiotic combined with bovine Immunoglobulins (IgG) designed to help those suffering from Small Intestine Bacterial Overgrowth (SIBO). All rights reserved.Small Intestine Bacterial Overgrowth (SIBO) requires special probiotics that can gently repopulate the microbiome without overpopulating the small intestine. MegaSporeProbiotic™ treatment resulted in changes in metabolism and increased bacterial diversity.īacillus Colon Microbial community Short-chain fatty acids.Ĭopyright © 2021 The Authors. The Firmicutes:Bacteroidetes ratio increased with treatment in the AC compartment. Overall, Akkermansia muciniphila, Bifidobacteria spp., and Firmicutes increased with treatment while Lactobacillus spp. Ammonium levels were significantly decreased during the final week of treatment (TC, P = 0.02 DC, P = 0.03). Propionate levels increased significantly in the TC (week 2, P = 0.02 week 3, P = 0.0019) and DC (week 2, P = 0.03) with treatment while lactate levels significantly decreased in the TC (week 3, P = 0.03). Changes in microbial community activity and composition between the control and treatment periods were evaluated for each colon compartment (ascending, transverse, and descending colon ). Following a stabilization period and a control period (2 weeks each), the reactor feed was supplemented with daily MegaSporeBiotic™ for 3 weeks (treatment period). The effects of MegaSporeBiotic™ on gut microbiota activity and community composition were evaluated for the first time using an in vitro model of the human gastrointestinal tract, the simulator of the human intestinal microbial ecosystem (SHIME®), under healthy conditions. (Bacillus indicus HU36, Bacillus subtilis HU58, Bacillus coagulans SC208, Bacillus licheniformis S元07, and Bacillus clausii SC109). MegaSporeBiotic™ is an oral, spore-based probiotic comprised of five Bacillus spp.
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